interstitial Syllabification: (in·ter·sti·tial)Pronunciation: /ˌintərˈstiSHəl/Definition of interstitial adjective of, forming, or occupying interstices:the interstitial space Ecology (of minute animals) living in the spaces between individual sand grains in the soil or aquatic sediments:the interstitial fauna of marine sandsDerivatives interstitially adverb interstitial in other Oxford dictionaries Definition of interstitial in the British & World English dictionary