iguana Syllabification: (i·gua·na)Pronunciation: /iˈgwänə/Definition of iguana noun a large, arboreal, tropical American lizard with a spiny crest along the back and greenish coloration, occasionally kept as a pet. Genus Iguana, family Iguanidae: two species, in particular the common green iguana (I. iguana) any iguanid lizard. Origin: mid 16th century: from Spanish, from Arawak iwanaiguana in other Oxford dictionaries Definition of iguana in the British & World English dictionary