hypoxanthine Syllabification: (hy·po·xan·thine)Pronunciation: /ˌhīpōˈzanˌTHēn/Definition of hypoxanthine noun Biochemistry a compound that is an intermediate in the metabolism of purines in animals and occurs in plant tissues. Alternative name: 6-hydroxypurine; chemical formula: C5H4N4O hypoxanthine in other Oxford dictionaries Definition of hypoxanthine in the British & World English dictionary