hypothesize Syllabification: (hy·poth·e·size)Pronunciation: /hīˈpäTHəˌsīz/Definition of hypothesize verb [with object] put (something) forward as a hypothesis:it was reasonable to hypothesize a viral causality [with clause]:they hypothesize that the naturally high insulin levels result from a “thrifty gene.”Derivatives hypothesizer noun hypothesize in other Oxford dictionaries Definition of hypothesize in the British & World English dictionary