hypoallergenic Syllabification: (hy·po·al·ler·gen·ic)Pronunciation: /ˌhīpōˌalərˈjenik/Translate hypoallergenic | into French | into Italian | into Spanish Definition of hypoallergenic adjective (especially of cosmetics and textiles) relatively unlikely to cause an allergic reaction. hypoallergenic in other Oxford dictionaries Definition of hypoallergenic in the British & World English dictionary