hypertonic Syllabification: (hy·per·ton·ic)Pronunciation: /ˌhīpərˈtänik/Definition of hypertonic adjective having increased pressure or tone, in particular. Biology having a higher osmotic pressure than a particular fluid, typically a body fluid or intracellular fluid. Physiology of or in a state of abnormally high muscle tone. Derivatives hypertoniaPronunciation: /-ˈtōnēə/ noun hypertonicityPronunciation: /ˌhīpərtəˈnisitē/ noun hypertonic in other Oxford dictionaries Definition of hypertonic in the British & World English dictionary