histamine Syllabification: (his·ta·mine)Pronunciation: /ˈhistəˌmēn, -ˌmin/Definition of histamine noun Biochemistry a compound that is released by cells in response to injury and in allergic and inflammatory reactions, causing contraction of smooth muscle and dilation of capillaries. A heterocyclic amine; chemical formula: C5H9N3 Derivatives histaminicPronunciation: /ˌhistəˈminik/ adjective Origin: early 20th century: blend of histidine and aminehistamine in other Oxford dictionaries Definition of histamine in the British & World English dictionary