haloperidol Syllabification: (hal·o·per·i·dol)Pronunciation: /ˌhalōˈperəˌdôl, -däl/Definition of haloperidol noun Medicine a synthetic antidepressant drug used chiefly in the treatment of psychotic conditions. Origin: 1960s: blend of halogen and piperidine + -olhaloperidol in other Oxford dictionaries Definition of haloperidol in the British & World English dictionary