grapefruit Syllabification: (grape·fruit)Pronunciation: /ˈgrāpˌfro͞ot/Translate grapefruit | into French | into German | into Italian | into Spanish Definition of grapefruit noun (plural same) 1a large, round, yellow citrus fruit with an acid, juicy pulp. 2the tree bearing the grapefruit. Citrus paradisi, family Rutaceae Origin: early 19th century: from grape + fruit (probably because the fruits grow in clusters)grapefruit in other Oxford dictionaries Definition of grapefruit in the British & World English dictionary