glucosamine Syllabification: (glu·co·sa·mine)Pronunciation: /glo͞oˈkōsəˌmēn, -min/Definition of glucosamine noun a crystalline compound which occurs widely in connective tissue, especially as a component of chitin. a synthesized form of this, taken to relieve arthritis pain. glucosamine in other Oxford dictionaries Definition of glucosamine in the British & World English dictionary