ganglioside Syllabification: (gan·gli·o·side)Pronunciation: /ˈgaNGglēəˌsīd/Definition of ganglioside noun Biochemistry any of a group of complex lipids that are present in the gray matter of the human brain. Origin: 1940s: from ganglion + -oside (see -ose2, -ide)ganglioside in other Oxford dictionaries Definition of ganglioside in the British & World English dictionary