gallstone Syllabification: (gall·stone)Pronunciation: /ˈgôlˌstōn/Translate gallstone | into Italian | into Spanish Definition of gallstone noun a small, hard crystalline mass formed abnormally in the gallbladder or bile ducts from bile pigments, cholesterol, and calcium salts. Gallstones can cause severe pain and blockage of the bile duct. gallstone in other Oxford dictionaries Definition of gallstone in the British & World English dictionary