extrapyramidal Syllabification: (ex·tra·py·ram·i·dal)Pronunciation: /ˌekstrəpəˈramidl/Definition of extrapyramidal adjective Anatomy & Medicine relating to or denoting nerves concerned with motor activity that descend from the cortex to the spine and are not part of the pyramidal system:extrapyramidal symptomsextrapyramidal in other Oxford dictionaries Definition of extrapyramidal in the British & World English dictionary