exergonic Syllabification: (ex·er·gon·ic)Pronunciation: /ˌeksərˈgänik/Definition of exergonic adjective Biochemistry (of a metabolic or chemical process) accompanied by the release of energy. The opposite of endergonic.Origin: mid 20th century: from ex-2 'out of' + Greek ergon 'work' + -icexergonic in other Oxford dictionaries Definition of exergonic in the British & World English dictionary