epidermolysis Syllabification: (ep·i·der·mol·y·sis)Pronunciation: /ˌepidərˈmäləsis/ (also epidermolysis bullosa /bəˈlōsə/)Definition of epidermolysis noun Medicine loosening of the epidermis, with extensive blistering of the skin and mucous membranes, occurring either after injury, or as a spontaneous and potentially dangerous condition, particularly in children. epidermolysis in other Oxford dictionaries Definition of epidermolysis in the British & World English dictionary