endorphin Syllabification: (en·dor·phin)Pronunciation: /enˈdôrfin/Definition of endorphin noun Biochemistry any of a group of hormones secreted within the brain and nervous system and having a number of physiological functions. They are peptides that activate the body’s opiate receptors, causing an analgesic effect. Origin: 1970s: blend of endogenous and morphineendorphin in other Oxford dictionaries Definition of endorphin in the British & World English dictionary