endoplasmic reticulum Syllabification: (en·do·plas·mic re·tic·u·lum)Pronunciation: /ˌendōˈplazmik riˈtikyələm/Definition of endoplasmic reticulum noun Biology a network of membranous tubules within the cytoplasm of a eukaryotic cell, continuous with the nuclear membrane. It usually has ribosomes attached and is involved in protein and lipid synthesis. endoplasmic reticulum in other Oxford dictionaries Definition of endoplasmic reticulum in the British & World English dictionary