drosophila Syllabification: (dro·soph·i·la)Pronunciation: /drəˈsäfələ/Definition of drosophila noun a small fruit fly, used extensively in genetic research because of its large chromosomes, numerous varieties, and rapid rate of reproduction. Genus Drosophila, family Drosophilidae: in particular D. melanogaster Origin:modern Latin, from Greek drosos 'dew, moisture' + philos 'loving'drosophila in other Oxford dictionaries Definition of drosophila in the British & World English dictionary