diastereoisomer Syllabification: (di·a·ste·re·o·is·o·mer)Pronunciation: /ˌdīəˌsterēōˈīsəmər/Definition of diastereoisomer noun Chemistry each of a pair of stereoisomeric compounds that are not mirror images of one another. Derivatives diastereoisomericPronunciation: /-ˌīsəˈmerik/ adjective diastereoisomer in other Oxford dictionaries Definition of diastereoisomer in the British & World English dictionary