dermatomyositis Syllabification: (der·mat·o·my·o·si·tis)Pronunciation: /dərˌmatəˌmīəˈsītis, ˈdərmətō-/Definition of dermatomyositis noun Medicine inflammation of the skin and underlying muscle tissue, involving degeneration of collagen, discoloration, and swelling, typically occurring as an autoimmune condition or associated with internal cancer. dermatomyositis in other Oxford dictionaries Definition of dermatomyositis in the British & World English dictionary