dedifferentiate Syllabification: (de·dif·fer·en·ti·ate)Pronunciation: /dēˌdifəˈrenSHēˌāt/Definition of dedifferentiate verb [no object] Biology (of a cell or tissue) undergo a reversal of differentiation and lose specialized characteristics. Derivatives dedifferentiationPronunciation: /-ˌrenSHēˈāSHən/ noun dedifferentiate in other Oxford dictionaries Definition of dedifferentiate in the British & World English dictionary