de novo Syllabification: (de no·vo)Pronunciation: /dā ˈnōvō, di/Definition of de novo adverb & adjective starting from the beginning; anew: [as adverb]:in a pure meritocracy, everyone must begin de novo [as adjective]:a general strategy for de novo protein designOrigin: early 17th century: Latin, literally 'from new'de novo in other Oxford dictionaries Definition of de novo in the British & World English dictionary