cytoskeleton Syllabification: (cy·to·skel·e·ton)Pronunciation: /ˌsītəˈskelitn/Definition of cytoskeleton noun Biology a microscopic network of protein filaments and tubules in the cytoplasm of many living cells, giving them shape and coherence. Derivatives cytoskeletalPronunciation: /-ˈskelitl/ adjective cytoskeleton in other Oxford dictionaries Definition of cytoskeleton in the British & World English dictionary