cytomegalovirus Syllabification: (cy·to·meg·a·lo·vi·rus)Pronunciation: /ˌsītəˈmegəlōˌvīrəs/ (abbreviation: CMV)Definition of cytomegalovirus noun Medicine a kind of herpesvirus that usually produces very mild symptoms in an infected person but may cause severe neurological damage in people with weakened immune systems and in the newborn. cytomegalovirus in other Oxford dictionaries Definition of cytomegalovirus in the British & World English dictionary