cuttlebone Syllabification: (cut·tle·bone)Pronunciation: /ˈkətlˌbōn/Definition of cuttlebone noun the flattened oval internal skeleton of the cuttlefish, which is made of white, lightweight, chalky material. It is used as a dietary supplement for caged birds and for making casts for precious metal items. cuttlebone in other Oxford dictionaries Definition of cuttlebone in the British & World English dictionary