creatinine Syllabification: (cre·at·i·nine)Pronunciation: /krēˈatnˌēn, -ˈatn-in/Definition of creatinine noun Biochemistry a compound that is produced by metabolism of creatine and excreted in the urine. An anhydride of creatine; chemical formula: C7H4N3O creatinine in other Oxford dictionaries Definition of creatinine in the British & World English dictionary