cardiomegaly Syllabification: (car·di·o·meg·a·ly)Pronunciation: /ˌkärdēōˈmegəlē/Definition of cardiomegaly noun Medicine abnormal enlargement of the heart. Origin: 1960s: from cardio- + Greek megas, megal- 'great'cardiomegaly in other Oxford dictionaries Definition of cardiomegaly in the British & World English dictionary