calutron Syllabification: (cal·u·tron)Pronunciation: /ˈkalyəˌträn/Definition of calutron noun a device that uses large electromagnets to separate uranium isotopes from uranium ore. It was developed in the 1940s to produce highly enriched weapons-grade uranium. Origin:from Cal(ifornia) U(niversity) (cyclo)troncalutron in other Oxford dictionaries Definition of calutron in the British & World English dictionary