backbone Syllabification: (back·bone)Pronunciation: /ˈbakˌbōn/Translate backbone | into French | into German | into Italian | into Spanish Definition of backbone noun 1the series of vertebrae extending from the skull to the pelvis; the spine. US the spine of a book. Biochemistry the main chain of a polymeric molecule. 2the chief support of a system or organization; the mainstay:these firms are the backbone of our industrial sector strength of character; firmness:he has the backbone to see us through this difficulty 3 Computing & Telecommunications a high-speed, high-capacity digital connection which forms the axis of a local or wide area network. backbone in other Oxford dictionaries Definition of backbone in the British & World English dictionary