autotune Syllabification: (au·to·tune)Pronunciation: /ˈôtōˌt(y)o͞on/ (also trademark Auto-Tune)Definition of autotune noun a device or facility for tuning something automatically, especially a piece of computer software that enables the correction of an out-of-tune vocal performance. autotune in other Oxford dictionaries Definition of autotune in the British & World English dictionary