anhydride Syllabification: (an·hy·dride)Pronunciation: /anˈhīˌdrīd/Definition of anhydride noun Chemistry the compound obtained by removing the elements of water from a particular acid. [usually with modifier] an organic compound containing the group C(O)OC(O), derived from a carboxylic acid. Origin: mid 19th century: from Greek anudros (see anhydrous) + -ideanhydride in other Oxford dictionaries Definition of anhydride in the British & World English dictionary