acetone Syllabification: (ac·e·tone)Pronunciation: /ˈasiˌtōn/Definition of acetone noun Chemistry a colorless volatile liquid ketone made by oxidizing isopropanol, used as an organic solvent and synthetic reagent. Chemical formula: CH3COCH3 Origin: mid 19th century: from acetic + -oneacetone in other Oxford dictionaries Definition of acetone in the British & World English dictionary