Theodora Syllabification: (The·o·do·ra)Pronunciation: /ˌTHēəˈdôrə/Definition of Theodora (circa 500–548), Byzantine empress; wife of Justinian. As Justinian’s closest adviser, she exercised considerable influence on political affairs and the theological questions of the time. Theodora in other Oxford dictionaries Definition of Theodora in the British & World English dictionary