Senegambia Syllabification: (Sen·e·gam·bi·a)Pronunciation: /ˌseniˈgambēə, -ˈgäm-/Definition of Senegambia a region in West Africa that consists of the Senegal and Gambia rivers and the area between them. It lies mostly in Senegal and western Mali. Senegambia in other Oxford dictionaries Definition of Senegambia in the British & World English dictionary