OD2 Syllabification: (OD) informalTranslate OD | into French | into Italian Definition of OD verb (OD's, OD'ing, OD'd) [no object] take an overdose of a drug:Spike had OD’d on barbiturates humorous have too much of something:I almost OD’d on mushroom salad noun an overdose of a narcotic drug. OD in other Oxford dictionaries Definition of OD in the British & World English dictionary