Nicene Creed Syllabification: (Ni·cene Creed)Pronunciation: /ˈnīsēn, nīˈsēn/Definition of Nicene Creed a formal statement of Christian belief that is widely used in Christian liturgies, based on that adopted at the first Council of Nicaea in 325. Nicene Creed in other Oxford dictionaries Definition of Nicene Creed in the British & World English dictionary