Newcastle, 1st Duke of Syllabification: (New·cas·tle, 1st Duke of)Pronunciation: /ˈn(y)o͞oˌkasəl/Definition of Newcastle, 1st Duke of (1693–1768), British statesman; prime minister 1754–56 and 1757–62; born Thomas Pelham-Holles. During his second term in office, he headed a coalition with William Pitt the Elder until 1761. Newcastle, 1st Duke of in other Oxford dictionaries Definition of Newcastle, 1st Duke of in the British & World English dictionary