Littleton Syllabification: (Lit·tle·ton)Pronunciation: /ˈlitl-tən/Definition of Littleton an industrial city in north central Colorado, south of Denver, scene of a shooting at Columbine High School in April 1999 in which 15 (including the two student gunmen) died and 21 were wounded; population 40,777 (est. 2008).
