Lewis, Sinclair Syllabification: (Lew·is, Sinclair)Pronunciation: /ˈlo͞o-is/Definition of Lewis, Sinclair (1885–1951), US novelist; full name Harry Sinclair Lewis. His satirical works include Main Street (1920), Babbitt (1922), and Elmer Gantry (1927). Nobel Prize for Literature (1930). Lewis, Sinclair in other Oxford dictionaries Definition of Lewis, Sinclair in the British & World English dictionary