Juno Syllabification: (Ju·no)Pronunciation: /ˈjo͞oˌnō/Definition of Juno 1 Roman Mythology the most important goddess of the Roman state, wife of Jupiter. She was originally an ancient Italian goddess. Greek equivalent Hera. 2 Astronomy an asteroid discovered in 1804, with a diameter of 152 miles (244 km). Juno in other Oxford dictionaries Definition of Juno in the British & World English dictionary