Isfahan Syllabification: (Is·fa·han)Pronunciation: /ˌisfəˈhän/ (also Esfahan /ˌesfə-/, Ispahan /ˌispə-/)Definition of Isfahan an industrial city in central Iran; population 1,602,110 (2006). It was the capital of Persia 1598–1722. Isfahan in other Oxford dictionaries Definition of Isfahan in the British & World English dictionary