Cosa Nostra Syllabification: (Co·sa Nos·tra)Pronunciation: /ˌkōsə ˈnōstrə, ˌkōzə/Definition of Cosa Nostra a US criminal organization resembling and related to the Mafia. Origin:Italian, literally 'our affair'Cosa Nostra in other Oxford dictionaries Definition of Cosa Nostra in the British & World English dictionary