Catherine de Médicis Syllabification: (Cath·er·ine de Mé·di·cis)Pronunciation: /də ˈmedəCHē/Definition of Catherine de Médicis (1519–89), queen of France; wife of Henry II; Italian name Catherine de' Medici. She ruled as regent 1560–74 during the minority reigns of her three sons: Francis II, Charles IX, and Henry III.
