Andes Syllabification: (An·des)Pronunciation: /ˈandēz/Translate Andes | into Italian | into Spanish Definition of Andes a major mountain system that runs the length of the Pacific coast of South America. It extends more than 5,000 miles (8,000 km), with a continuous height of more than 10,000 feet (3,000 m). Its highest peak is Aconcagua. Andes in other Oxford dictionaries Definition of Andes in the British & World English dictionary